Department of Neuroscience
Present PI Affiliations:
George Wilcox, Carolyn Fairbanks
Years of University Contribution: 20
Awards: Patrick J. Manning
Fairbanks, CA, Posthumus,
IJ, Kitto, KF, Stone, LS and Wilcox, GL (2000) Moxonidine, a
selective imidazoline/a2 adrenergic receptor agonist, synergizes with
morphine and deltorphin II to inhibit substance P-induced behavior in
mice. Pain 84:13-20.
Fairbanks, CA, Schreiber,
KL, Brewer, KL, Yu, CG, Stone, LS, Kitto, KF, Nguyen, HO, Grocholski,
BM, Shoeman, DW, Kehl, LJ, Regunathan, S, Reis, DJ, Yezierski, RP and
Wilcox, GL (2000) Agmatine reverses pain induced by inflammation, neuropathy,
and spinal cord injury. Proceedings of the National Academy of Sciences
Fairbanks, CA, Stone,
LS, Kitto, KF, Nguyen, HO, Posthumus, IJ and Wilcox, GL (in press)
Alpha2C adrenergic receptors mediate spinal analgesia and adrenergic-opioid
synergy. J. Pharmacol. Exp. Therap.
Giovengo, SL, Kitto,
KF, Kurtz, HJ, Velazquez, RA and Larson, AA (1999) Parenterally
administered kainic acid induces a persistent hyperalgesia in the mouse
and rat. Pain 83:347-58.
Kitto, KF, Haley,
JE and Wilcox, GL (1992) Involvement of nitric oxide in spinally mediated
hyperalgesia in the mouse. Neurosci. Lett. 148:1-5.
Larson, AA and Kitto,
KF (1995) Sensitization to the behavioral effect of kainic acid
in the mouse is mediated by nitric oxide. J. Pharmacol. Exp. Ther.
Larson, AA and Kitto,
KF (1997) Mutual antagonism between nerve growth factor and substance
P N-terminal activity on nociceptive activity in mice. J. Pharmacol.
Exp. Therap. 282:1345-1350.
Laughlin, TM, Kitto,
KF and Wilcox, GL (1998) Redox manipulation of NMDA receptors in
vivo: alteration of acute pain transmission and dynorphin-induced allodynia.
Roerig, S, Lei, S,
Kitto, K, Hylden, JLK and Wilcox, GL (1992) Spinal interactions
between opioid and noradrenergic agonists in mice: Multiplicitivity
involves d and a2 receptors. J. Pharmacol. Exp. Ther. 262:365-374.
Stone, LS, Macmillan,
L, Kitto, KF, Limbird, L and Wilcox, GL (1997) The a2a-adrenergic
receptor subtype mediates spinal analgesia evoked by a2 agonists and
is necessary for spinal adrenergic/opioid synergy. J. Neurosci. 17:7157-7165.
Velazquez, RA, Kitto,
KF and Larson, AA (1997) CP-96,345, which inhibits [3H] substance
P binding, selectively inhibits the behavioral response to intrathecally
administered N-methyl-D-aspartate, but not substance P, in the mouse.
J. Pharmacol. Exp. Therap. 281:1231-1237.