H. Oanh X. Nguyen, B.S.
Coordinator


Department of Pharmaceutics

Present PI Affiliation: George Wilcox, Carolyn Fairbanks
Years of University Contribution: 12

I joined Dr. Wilcox's laboratory in June 1994 as part of a high school summer research internship program and returned the following summer for a second summer research experience. As it turned out, I remained as a part-time student laboratory assistant for the duration of my college years. Following graduation, I participated in some graduate level coursework in the Graduate Program in Pharmacology. In May 2001, I joined the University of Minnesota College of Pharmacy as a Professional and Administrative Research Coordinator with the research program of Dr. Carolyn Fairbanks. I tremendously enjoy being a part of the scientific community here at the University of Minnesota; I particularly enjoy attending weekly seminars and journal clubs of the Depts of Neuroscience, Pharmaceutics and Pharmacology. I look forward to many more years working with my laboratory team members as well as members of the Center for Pain Research.

During my time in the lab, I have acquired knowledge and mastery in a variety of animal and molecular biology experimental assays including: intrathecal injection, interarticular injection, mechanical and thermal sensory assessment, spinal-nerve ligation surgery, trans-electrical nerve stimulation, antibody production, immunocytochemistry, and genotyping. In the future I hope to incorporate more genomics oriented techniques. In addition to my experimental skills, I am also responsible for administrative tasks including: personnel training and scheduling, laboratory supply ordering, chemical database, research subject forms database, selection and optimization of equipment and methods for the laboratory. I also contribute to the management of the University of Minnesota Center for Pain Research.

Publications:

Goracke-Postle CJ, Nguyen HO, Stone LS, Fairbanks CA. (2006) Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17(1):13-7.

King EW, Audette K, Athman GA, Nguyen HO, Sluka KA, Fairbanks CA. (2005) Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors. Pain 115(3):364-73.

Nguyen HO, Goracke-Postle CJ, Kaminski LL, Overland AC, Morgan AD, Fairbanks CA. (2003) Neuropharmacokinetic and dynamic studies of agmatine (decarboxylated arginine). Ann N Y Acad Sci. 1009:82-105.

Fairbanks, CA, Stone, LS, Kitto, KF, Nguyen, HO, Posthumus, IJ, Wilcox, GL. (2002) Alpha2C adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J. Pharmacol. Exp. Therap. 300(1):282-90.

Fairbanks, CA, Nguyen, HO, Grocholski, BM, Wilcox, GL. (2000) Moxonidine, a selective imidazoline-a2-adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice. Anesthesiol. 93:765-773.

Fairbanks, CA, Schreiber, KL, Brewer, KL, Yu, CG, Stone, LS, Kitto, KF, Nguyen, HO, Grocholski, BM, Shoeman, DW, Kehl, LJ, Regunathan, S, Reis, DJ, Yezierski, RP, Wilcox, GL. (2000) Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci U S A. 97:19584-10589.

Stone LS, Fairbanks CA, Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, Wilcox GL. (1997) Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport 8(14):3131-5.

 

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