Department of Pharmaceutics
Present PI Affiliation:
George Wilcox, Carolyn Fairbanks
Years of University Contribution: 12
I joined Dr. Wilcox's
laboratory in June 1994 as part of a high school summer research internship
program and returned the following summer for a second summer research
experience. As it turned out, I remained as a part-time student laboratory
assistant for the duration of my college years. Following graduation, I
participated in some graduate level coursework in the Graduate Program
in Pharmacology. In May 2001, I joined the University of Minnesota College
of Pharmacy as a Professional and Administrative Research Coordinator with
the research program of Dr. Carolyn Fairbanks. I tremendously enjoy being
a part of the scientific community here at the University of Minnesota;
I particularly enjoy attending weekly seminars and journal clubs of the
Depts of Neuroscience, Pharmaceutics and Pharmacology. I look forward
to many more years working with my laboratory team members as well as members
of the Center for Pain Research.
During my time in the
lab, I have acquired knowledge and mastery in a variety of animal and molecular
assays including: intrathecal
injection, interarticular injection, mechanical and thermal sensory assessment,
spinal-nerve ligation surgery, trans-electrical nerve stimulation, antibody
production, immunocytochemistry, and genotyping. In the future I hope to
incorporate more genomics oriented techniques. In addition to my experimental
skills, I am also responsible for administrative tasks including: personnel
training and scheduling, laboratory supply ordering, chemical database,
research subject forms database, selection and optimization of equipment
for the laboratory. I also contribute to the management of the University
of Minnesota Center for Pain Research.
Goracke-Postle CJ, Nguyen HO, Stone LS, Fairbanks CA. (2006) Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17(1):13-7.
King EW, Audette K, Athman GA, Nguyen HO, Sluka KA, Fairbanks CA. (2005) Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors. Pain 115(3):364-73.
Nguyen HO, Goracke-Postle CJ, Kaminski LL, Overland AC, Morgan AD, Fairbanks CA. (2003) Neuropharmacokinetic and dynamic studies of agmatine (decarboxylated arginine). Ann N Y Acad Sci. 1009:82-105.
Fairbanks, CA, Stone, LS, Kitto, KF, Nguyen, HO, Posthumus, IJ, Wilcox, GL. (2002) Alpha2C adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J. Pharmacol. Exp. Therap. 300(1):282-90.
Fairbanks, CA, Nguyen,
HO, Grocholski, BM, Wilcox, GL. (2000) Moxonidine, a selective
imidazoline-a2-adrenergic receptor agonist, produces spinal synergistic
antihyperalgesia with morphine in nerve-injured mice. Anesthesiol.
Fairbanks, CA, Schreiber,
KL, Brewer, KL, Yu, CG, Stone, LS, Kitto, KF, Nguyen, HO, Grocholski,
BM, Shoeman, DW, Kehl, LJ, Regunathan, S, Reis, DJ, Yezierski, RP,
Wilcox, GL. (2000) Agmatine reverses pain induced by inflammation, neuropathy,
and spinal cord injury. Proc Natl Acad Sci U S A.
Stone LS, Fairbanks CA, Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, Wilcox GL. (1997) Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport 8(14):3131-5.